How it works

NSM stimulation – how it works

NSM stimulation was developed by Dr. Albrecht Molsberger, Prof. UNC/USA, PD, MD. It is based on the stimulation of the body’s own electrical fields. Bioelectrical fields produced by the body govern the movement of cells and interact with ions and certain proteins involved in cell metabolism.

Immediate effects

According to the current literature, the rapid effects of neurostimulation – improvements are often felt within 90 minutes – are most likely due to the neutralization of pro‑inflammatory hormones. These messenger substances, known as cytokines, include substance P, bradykinin, TNF alpha, interleukins 1, 6 and 8, and norepinephrines. All of these cytokines promote inflammation and amplify nerve pain (1, 3-5). At the same time, neurostimulation appears to stimulate growth-promoting cytokines. These include platelet-derived growth factor (PDGF), transforming growth factor beta (TGF beta), and insulin-like growth factor (ILG) – all factors that are also used in autologous biologicals (e.g. platelet rich plasma or PRP) (2). These cell hormones trigger the regeneration of tissue and promote permanent healing.

Long-term effects

A second mechanism by which NSM produces its effects is believed to be based on the ability of cells to move in response to certain bioelectrical fields. NSM stimulation strengthens these electric fields in very specific ways. The cells (e.g. fibrocytes) are encouraged to “migrate” to exactly where they are needed in order to regenerate damaged tissue. This may explain the long-term effectiveness of NSM stimulation.

Book and video clip

Further information concerning the scientific basis underlying this method can be found in the ebook by Albrecht Molsberger (german only)


Scientific literature
1. McCaig et al. Controlling cell behavior electrically: current views and future potential. Physiological Reviews (2005) vol. 85 (3) pp. 943-782. Creaney and Hamilton. Growth factor delivery methods in the management of sports injuries: the state of play. British Journal of Sports Medicine (2008) vol. 42 (5) pp. 314-3203. Robinson. Electric Fields Review. The Journal of Cell Biology (1985) pp.2023-20274. Shah et al. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Archives of physical medicine and rehabilitation (2008) vol. 89 (1) pp. 16-23

5. Shah. An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. Journal of Applied Physiology (2005) vol. 99 (5) pp. 1977-1984

6. Zhao et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN. Nature (2006) vol. 442 (7101) pp. 457-460

Leave a Reply

Your email address will not be published. Required fields are marked *